Highlights: Over 500 days have passed since the escalation of conflict in Sudan in April 2023. Healthcare should never be a target. However, since April 2023, 106 attacks on healthcare have been verified, resulting in 183 deaths and 125 injuries. Many more undocumented attacks are likely to have occurred. There is an ongoing cholera outbreak in Sudan. Since the beginning of the outbreak, nearly 10 000 cases and 315 deaths (CFR 3.3%) have been reported as of 15 September 2024. WHO supports the Sudan Federal Ministry of Health (FMoH) through different pillars. An oral polio vaccination campaign took place in seven states (River Nile, Gedaref, Kassala, Northern and Red Sea, Blue Nile and White Nile) in Sudan from 19 to 22 August 2024. WHO helped vaccinate more than 2.9 million children under five years of age. In conjunction with the polio vaccination campaign, an oral cholera vaccination campaign was conducted in one locality of Kassala State from 19 to 22 August 2024, vaccinating 51 000 people aged older than one year.